22 September 2021 Modeling heart disease in a dish: unraveling arrhythmogenic cardiomyopathy Back to news Researchers from the group of Eva van Rooij studied pathological aspects of the genetic heart disease arrhythmogenic cardiomyopathy (ACM). They identified the cellular origin and molecular mechanisms underlying cardiac fibro-fatty remodeling in ACM patients. Data generated in this study allowed a better molecular understanding of ACM pathogenesis and presented a novel target for therapeutic intervention. Their study was published in Science Translational Medicine on 22 September. Arwa Kohela, one of the researchers on this study, explains more in the video below. Publication Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Arwa Kohela, Sebastiaan J. van Kampen, Tara Moens, Martijn Wehrens, Bas Molenaar, Cornelis J. Boogerd, Jantine Monshouwer-Kloots, Ilaria Perini, Marie JoseĢ Goumans, Anke M. Smits, J. Peter van Tintelen, and Eva van Rooij. Science Translational Medicine 2021.
