ERC-starting grant for Marvin Tanenbaum and Jop Kind

ERC-starting grant for Marvin Tanenbaum and Jop Kind

Marvin Tanenbaum and Jop Kind, both group leader at the Hubrecht Institute, are awarded an ERC-starting grant. The ERC-starting grants are awarded to support up-and-coming research leaders who have recently established their own research team in Europe.

Tanenbaum: Single molecule observation and manipulation of gene expression dynamics to dissect mechanisms of cell cycle entry

“Gene expression is a highly dynamic and inherently variable process. Yet, it needs to be tightly regulated, especially during the cell cycle, when continuous widespread changes occur to the proteome. A detailed mechanistic understanding of how cells make sure they express the correct amount of each protein is critical to further our understanding of cell cycle control. Marvin Tanenbaum will apply sophisticated live-cell analyses to study how protein levels are controlled in single cells, and how such control affects the cellular decision to the progress through the cell cycle. ”

Kind: Single-cell epigenomics: quantifying epigenetic changes in individual cells using DamID

“A central question in biology is how cell-to-cell variability arises from the heritable acquisition of cell type-specific gene expression programs. Key in understanding cellular specification is to elucidate the epigenetic mechanism that underlies transcriptional heterogeneity. However, current techniques to profile the epigenome require populations of cells and consequently present ensemble averages of the underlying biology. Therefore, to grasp the molecular concept behind the cellular acquisition of heritable traits it is essential to develop techniques to profile the epigenome at the single-cell level. The goal of this proposal is to develop a comprehensive single-cell epigenomic toolbox to work towards elucidating the molecular mechanism behind cellular specification.”